The UPRISE project aims to enhance understanding of the causal relationship between airborne UFP exposure and the increased risk of ABOs such as PTB. Additionally, it seeks to determine the contribution of MNPs to air pollution levels, and to explore if such a causal relationship exists for exposure to MNPs, in particular for sizes smaller than 10 μm in the largest dimension, and including polymers like polyethylene, polystyrene, polyvinyl chloride, polyethylene terephthalate, polymethyl methacrylate and polyamide, which sum up the most demanded polymer types in Europe. These MNPs are generated by road traffic (tire wear particles and brake wear particles), diesel combustion and other sources near densely populated areas (such as ports, airports, industries, etc.).
Through comprehensive multidisciplinary and participatory research involving epidemiologists, neonatologists, gynaecologists, toxicologists, environmental scientists, expecting parents’ representatives, and public health authorities, our work will offer crucial insights into causal relationships and biological mechanisms. This contribution will aid in evidence-based policy recommendations, the refinement of air quality standards for airborne UFPs and MNPs, and raising awareness among the target group of affected parents. Consequently, these findings will facilitate the development of interventions to safeguard the vulnerable prenatal period and mitigate its long-term impact, reducing the risk of chronic, NCD for newborns. By addressing a significant factor contributing to the global rise in PTB, this project holds potential for alleviating the burden of metabolic, respiratory, cardiovascular, renal, and neurodevelopmental disorders, commonly observed in extremely preterm infants throughout their lives. By prioritizing the impact of these pollutants on neonatology, UPRISE pursues an ambitious yet achievable objective of reducing PTB and subsequently curbing the associated heavy burden of NCD.
Total budget: €8,0 million, No. Partners: 14, Duration: 60m
Funded by the European Union (grant no. 101156622)
